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米国特許 英語

米国特許 英語

Blood flow improving agent
WO 2010095690 A1

要約書

Disclosed is a blood flow improving agent that is comprised of natural compositions that are complementary to each other and that increases blood flow activity and circulation, as well as facilitating the decomposition, detoxification, and elimination of poisons accumulated in the body; further disclosed is a manufacturing method therefor. This blood flow improving agent is formed by blending, in nanobubble water in which oxygen is dissolved, a nanocolloided marine organic compound, multiple trace elements containing nanocolloided minerals extracted from mineral ore, and nanocolloided vegetable minerals and amino acid derived from fulvic acid.

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特許請求の範囲(11) 日本語から翻訳

1. Blood flow improving agent consisting of marine organic compounds in water, the nano-colloid is incorporated.

2. Amino acids and plant minerals fulvic acids derived from the nano-colloid is made to further contain,

The amino acid is selected from the group consisting claim 1 wherein aspartic acid, Torishirina, serine, glutamic acid, Gurishirin, alanine, cystine, valine, Mechiorin, Iwarorin, Reushin, tyrosine, Fenarin, histidine, lysine, ammonia, Arejin, proline, leucine, threonine blood flow improving agent. 

3. Trace elements including a plurality of minerals extracted from ore, is being further contain,

Wherein the ore, blood flow improving agent according to claim 2, wherein the corrosion granite. 

4. Said water, blood flow improving agent according to any one of claims 1 to 3, wherein the nanobubbles water dissolved oxygen or ozone.

5. The cell diameter marine organic compound which is the nano-colloid, blood flow improving agent according to any one of claims 1 to 4, wherein a 30 ~ 50nm.

6. Blood flow improving agent according to any one of claims 1 to 5, wherein the cell diameter of amino acids and plant minerals fulvic acids derived from the the nano-colloid is formed by being dispersed in water at 30 ~ 50nm.

7. The cell diameter of nanobubbles water dissolved ozone or the oxygen, blood flow improving agent according to any one of claims 1 to 6 comprising bubbles 30 ~ 50nm is dispersed in water.

8. A process for the preparation of the blood flow improving agent according to claim 1,

A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Consisting of the step of filling the purified water marine organic compound which is (3) nano-colloid, method of blood flow improving agent. 

9. A process for the preparation of the blood flow improving agent according to claim 2,

A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Consisting of the step of filling the purified water minerals and amino acids marine organic compound which is (3) nanocolloid of Plants of fulvic acid-derived method of manufacturing a blood flow improving agent. 

10. A process for the preparation of the blood flow improving agent according to claim 3,

A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Comprising a marine organic compound which is (3) nano-colloid, and a step of filling to the purified water and amino acids and minerals vegetable fulvic acid-derived, trace elements, method of the blood flow improving agent. 

11. Step (1) is a step of processing the nanobubbles water purified pure water reverse osmosis membrane device, and dissolved oxygen or ozone above,

After step (2) was washed with a filling container with nanobubbles water dissolved ozone or oxygen wherein a step of filling the container nanobubbles water dissolved oxygen or ozone, blood flow improving agent according to claim 10 method of manufacturing. 

明細書 日本語から翻訳

Blood flow improving agent 
 Improve blood flow agents and the present invention relates to a method of manufacturing the same.  More particularly, blood flow improving agent as a starting material only composition of natural and stable dispersed and fulvic acids containing vegetable and mineral trace elements and a plurality of marine organic compound was adjusted to 30 ~ 50nm particle size and its relates to a process for the production. 
 Conventionally, health foods and the like to extract the natural component assembly, and a form such as tablets or beverages it has attracted attention.  That of the natural composition minute, particular importance is an essential trace elements and minerals that can not be ingested in the diet everyday, these are necessary in order to compensate for the nutrition and lack of improvement of lifestyle-related diseases are known are.  However, sometimes wide variety of tastes of the individual and diversification of life, even when it is ingested health foods they necessarily, the excess or deficiency appropriately component or components determined deficiency in the body, the missing it can not be said that can take without.  Therefore, it is impossible to prevent any disease, it may be disease of unknown cause, lifestyle-related diseases, allergies, etc., a state not healthy without the disease.  However, even a disease of unknown cause them, as a common point of the cause, "something or deficiency, it is not enough," it is understood at least.  And as the cause of the deficiency, it is believed the present invention is not limited to food additives, environmental pollution substances, heavy metals, and adverse drug reactions, DNA is not recognized and that interfere with the normal metabolism.  In addition, if the normal metabolism is interrupted in this way, that the blood flow is reduced even know. 
 The present invention has been made in view of the problems of the prior art, promotes the catalytic amino acids and enzymes containing a metal, as the natural substances having a work leading to activation of the biological activation and or puffed cell amino acids and minerals and of vegetable that nano colloid of fulvic acid is an electrolyte of the strongest, will be extracted from the ore minerals, It is to be understood that it can not be ingested diet everyday, in the body and replaced by other elements nano-colloid and marine organic compounds extracted essential mineral is a substance that can not be synthesized, essential trace element, and ultra-trace elements, from seaweed which is indispensable to the homeostasis and function hormone balance, or purified water, ozone or oxygen By nanobubble water to be dissolved to and incorporated into the nano-bubble water dissolved ozone, the blood that consists of composition minute natural that Ae complement each other enhanced decomposition of toxins accumulated in the body and circulation activity and blood flow more, detoxification and excretion flow improving agent and an object to obtain a manufacturing method thereof. 
 Ingredients reason the technical background that nanocolloid of the present invention, components for the purpose of stabilization unrelated bulking agent and stabilizer, a component or a preservative had been used in the stabilization of the components according to the prior art Since those chemically synthesized than a few they had to seek high dispersion stability only effective ingredient in the drug.  Therefore, branch point decrease gradually organic iodine is a marine organic compound, the particle size of the fulvic acid, inter-particle attraction is the equilibrium while observing the floating or settling of component room temperature area (18-26 degrees before and after) It is obtained by find a niche. 
From the results of observation, I have observed equilibrium of attractive force between particles of 100nm per desirable about.  It is one method then as a solvent nanobubbles water consideration was set to 30 ~ 50nm. 
The present invention is a blood flow improving agent from water and marine organic compounds as nano-colloid is incorporated. 
Further, amino acids and plant minerals fulvic acids derived from the nano-colloid is made is contained further, the said amino acid, another aspect of the present invention, aspartic acid, Torishirina, serine, glutamic acid, Gurishirin, alanine, cystine , is the blood flow improving agent valine, Mechiorin, Iwarorin, Reushin, tyrosine, Fenarin, histidine, lysine, ammonia, Arejin, proline, leucine, threonine. 
In addition, trace elements including a plurality of minerals extracted from ore, is being further comprising, said ore, another aspect of the present invention is a blood flow improving agent is a corrosion granite. 
Said water is a nanobubbles water dissolved oxygen or ozone is preferred. 
It cell diameter marine organic compound which is the nano-colloid is a 30 ~ 50nm is preferable. 
The cell diameter of amino acids and plant minerals fulvic acids derived from the the nano-colloid is formed by being dispersed in water at 30 ~ 50nm is preferable. 
The cell diameter of nanobubbles water dissolved ozone or the oxygen becomes bubbles 30 ~ 50nm is dispersed in water is preferred. 
Further, the present invention is a manufacturing method of the blood flow improving agent, 
A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Consisting of the step of filling the purified water marine organic compound which is (3) nano-colloid is a method of the blood flow improving agent. 
Further, another aspect of the present invention is a manufacturing method of the blood flow improving agent, 
A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Consisting of the step of filling the purified water amino acids and minerals marine organic compound which is (3) nanocolloid of Plants of fulvic acid-derived, is a method of the blood flow improving agent. 
Furthermore, another aspect of the present invention is a manufacturing method of the blood flow improving agent, 
A process for purifying pure water (1) reverse osmosis membrane apparatus, 
A step of filling the container purified water obtained in step (2) (1), 
Comprising a marine organic compound which is (3) nano-colloid, and a step of filling to the purified water and amino acids and minerals vegetable fulvic acid-derived, trace elements, it is the method of the blood flow improving agent. 
Step (1) is a step of processing the nanobubbles water purified pure water reverse osmosis membrane device, and dissolved oxygen or ozone, and a step (2), nanobubbles water dissolved oxygen or ozone above the that after it was washed with a filling container, is a step of filling the container nanobubbles water dissolved oxygen or ozone is preferred. 
 According to the present invention, blood flow improving agent comprising the constituents by natural that Ae complement each other enhanced degradation of toxins accumulated in the body and circulatory activity and blood flow, detoxification, and excretion, and it is possible to obtain a manufacturing method thereof. 
And that the organic molecule with a foreign substance toxicity and remaining in the body, promotes oxidation by reaction with an organic iodine low molecular weight, is enhanced degradation, detoxification, and excretion, organic iodine promotes cell death of cells aged Above engulfment is in the closed circulation of the lymph, encouraging that a new cell is born under the overall integrity of the cell is characterized by the action of two opposing.  And can be extracted with high product purity only iodine component in order to obtain this effect, it is that it has trimmed colloid particle size too. 
The 20 kinds of amino acids in the top that has hormone action that are essential to life support by peptide bonds, neurotransmission action, antimicrobial activity, to increase the absorption skin, mouth, mucous membranes, such as from the small intestine fulvic acid is an organic electrolyte is efficient and has a function of preparing the physical condition and other polysaccharides, vitamins, enzymes and the like. 
 Is a flowchart illustrating a method for extracting marine organic compound formed by the nanocolloid of the present invention.   Is a flowchart illustrating a method for extracting minerals and amino acids of vegetable fulvic acids derived from the present invention.   Is a flowchart illustrating a method for extracting trace elements including a plurality of minerals extracted from the ore of the present invention.   Is a flowchart illustrating a method of manufacturing a blood flow improving agent according to an exemplary embodiment of a blood flow improving agent of the present invention (Example 1).   Is a flowchart illustrating a method of manufacturing a blood flow improving agent according to an exemplary embodiment of a blood flow improving agent of the present invention (Example 3).   Is a flowchart illustrating a method of manufacturing a blood flow improving agent according to an exemplary embodiment of a blood flow improving agent of the present invention (Example 5). 
 The present invention is a blood flow improving agent from water and marine organic compounds as nano-colloid is incorporated. 
Is not particularly limited as water, purified water or it is a nanobubbles water dissolved oxygen or ozone described later is preferable. 
The marine organic compound formed by the nano-colloid, refers to those nano-colloid as, for example, grain size becomes 30 ~ 50nm organic compounds derived from seaweed Nemacystus, advance, and kelp, marine organic The components that make up the compound, brown, ph5 ~ 6, 1 ~ 2cm Transparency, all iodine 70 ~ 80ppm, 10ppm or less heavy metals, arsenic less than 10ppm, viable cell count below 1000/ml, yeast in liquid without viscosity 100/ml or less, mold 100/ml or less, oxidation-reduction potential an overview, things 220/mlv following may be mentioned.  By using marine organic compound is within this range, protect the thyroid from radioactive iodine in food and the atmosphere, the internal cell destruction if the optimum range in vivo abundance organic iodine containing marine organic compound it is possible to have the potential to forestall.  They also are known as organic compounds having antitumor activity, the growth effects healthy.  The particle size is approximately 100nm ~ 1000μm, typically, the state of the initial extraction of marine organic compound is one in which the width of the particle size is very large, it can not exhibit sufficiently the functions and effects. 
The amount of the marine organic compound, 0.001 to 0.005% is preferred with the nanobubbles 1L of water or the water.  If the amount is less than 0.001%, there is a problem that less than the optimal range to be present in the body, if there is an optimum weight range thyroid if it exceeds 0.005%, and is excreted in the external.  Incidentally, there is a problem if the particle size of the marine organic compound is out of the range of 30 ~ 50nm, the dispersion stability is lowered. 
As shown in FIG 1, the step of extracting the organic compound as a raw material, seaweed, step of purifying the extract, the step of concentrating the purified product, marine organic compound formed by the nano-colloid is grain 30 ~ 50nm is stored through steps to control through the step of examining the particle diameter, and a step of pasteurization.  Is not particularly limited as extraction method, but from the viewpoint separation and recovery of the target substance can be easily, supercritical extraction with (Ltd. Mitsubishi Kakoki Kaisha, for example) supercritical extraction apparatus granules are preferred.  Further, as a method to control the particle size of 30 ~ 50nm, but are not limited to, it is possible to use, for example, micro-nano bubble generating device (Road, Kyowa machine 設製).  In addition, particle size of may be confirmed by zeta potential.  Sterilization temperature was 100 ℃ or less at a low temperature, 42 ~ 80 ℃, more preferably is 60 ~ 63 ℃ further.  The sterilization time 30 to 60 minutes is preferable, more preferably 30 minutes or less.  The storage temperature, 0 ~ 3 ℃ is preferred. 
The nano-colloid is a state in which bubbles approximately 5000 exists in 1mm 3. 
According to the literature of Industrial Science and Technology Institute, activate the function of micro-organisms and useful bacteria that are present in vivo, bioactive effect of nano-bubble water, corner of capillary components necessary blood flow and activity of aerobic It is obtained by considering the dense cohesive helps to deliver up people.  The literature and ditto, originally, nanobubbles water dissolved ozone, bacteria free radicals are generated by receiving high temperature, high pressure at the moment to be crushed in water bubble remains not rise to the surface of the water, according to the study of Tokyo Medical and Dental University possibility is to kill the virus and have been described.  As is apparent from these nanobubbles water dissolved oxygen and, nanobubbles water dissolved ozone can be said to be a water highly safe with no survivability Unlike chemical components. 
Further, amino acids and plant minerals fulvic acids derived from the nano-colloid is made is contained further, the said amino acid, another aspect of the present invention, aspartic acid, Torishirina, serine, glutamic acid, Gurishirin, alanine, cystine , is the blood flow improving agent valine, Mechiorin, Iwarorin, Reushin, tyrosine, Fenarin, histidine, lysine, ammonia, Arejin, proline, leucine, threonine. 
For amino acid fulvic acid derived from aspartic acid, Torishirina, serine, glutamic acid, Gurishirin, alanine, cystine, valine, Mechiorin, Iwarorin, Reushin, tyrosine, Fenarin, histidine, lysine, ammonia, Arejin, proline, leucine, threonine, and the like .  In addition, fulvic acid iron, fulvic acid salts other than overlaps the trace element for mineral. 
Here, the fulvic acid has a work leading to activation of a living body, an organic electrolyte strongest compositions include natural and adsorb heavy metals, having a scavenger activity and chelating effect of excretion thereto It can be said Improve It keeps electrochemical equilibrium with a substance to convey current to the equilibrated material in contact and provide energy to biological properties, free radical scavengers (cleaning agents) and anti-oxidants.  Based on the equilibrium cell needs, as the electron donor, it is the receptor of the electrons at certain times.  Chemical lose donate as a donor electrons in an oxidation reaction, and one receiving as an electron receptor active substances in the reduction reaction part of the reaction induced.  At this time, working as an electrode have been reported in the literature of many trace elements of many kinds.  Fulvic acid to detoxify pollutants pesticides accumulated in the body, additives, dioxin, and heavy metals, that the adsorption is related to the chemicals present in the environment before or after you made to the amount and concentration that could become dangerous to biological is.  In recent years, it is a useful food chain rapidly have been studied fulvic acid having such properties.  It has not yet been to elucidate the whole picture, but is also useful in plants as well as human body has been demonstrated many.  Was subjected to a germination test bean sprout As an example, the difference obvious growth was observed. 
Observation of the state of germination by placing the seed sprouts on cotton was placed in each container (which was diluted 1500-fold) blood flow improving agent of the present invention with mineral water and tap water of the present invention, blood flow sprouts germinated using the improving agent has demonstrated the differences (in length) growth nearly doubled compared to other water. 
The amount of amino acids and minerals, 0.005 to 0.009% is preferred per nanobubble 1L of water or the water, 0.005% is particularly preferred.  If the amount is less than 0.004%, there is a problem is a problem of not less than the optimal range to be present in the body, optimal weight range than is needed in the body that is excreted when it exceeds 0.01%, some. 
As shown in Figure 2, amino acids and minerals vegetable fulvic acid-derived, is preserved through step of filtering impurities from the fulvic acid, a step of sterilizing.  But are not limited to a method of filtering impurities, but in general, it is filtered by using a filter 1.000 micro, micro 5.000, 10.000 micro and fine sequentially. 
60 ~ 63 ℃ is preferred sterilization temperature.  In addition, the sterilization time, 30 minutes is preferred. 
For high-temperature sterilization, there is a problem in the three-dimensional structure of the amino acid and some of the collapse with the exception of the mineral, biological activity is lost.  The storage temperature, 0 ~ 3 ℃ is preferred. 
In addition, trace elements including a plurality of minerals extracted from ore, is being further comprising, said ore, another aspect of the present invention is a blood flow improving agent is a corrosion granite. 
For trace elements including a plurality of minerals extracted from the ore, as trace elements, calcium, phosphorus, magnesium, potassium, sodium, selenium, silicon, germanium, zinc, manganese, iron, copper, cobalt, nickel, molybdenum, lithium , vanadium, tungsten, barium, titanium, aluminum, strontium, and fluorine, and the like.  Ore is not particularly limited, corrosion granite are generally preferred.  The amount of the trace elements, 0.001 to 0.007% is preferred per nanobubble 1L of water or the water, 0.005% is particularly preferred.  If the amount is less than 0.001%, there is a problem that less than the optimal range to be present in the body, optimal weight range than is needed in the body are excreted when it exceeds 0.008%. 
As shown in Figure 3, trace elements, trace elements including a plurality of minerals extracted from ore are those containing purified as a stable above components was obtained. 
It cell diameter marine organic compound which is the nano-colloid is a 30 ~ 50nm is preferable. 
The cell diameter of amino acids and plant minerals fulvic acids derived from the the nano-colloid is formed by being dispersed in water at 30 ~ 50nm is preferable. 
The cell diameter of nanobubbles water dissolved ozone or the oxygen becomes bubbles 30 ~ 50nm is dispersed in water is preferred. 
In the present invention, nano bubble water dissolved oxygen and nano bubble water dissolved ozone is a solvent to be mixed marine and organic compounds, trace elements and more than one, and the amino acids and minerals plant of fulvic acid-derived, this nanobubbles water dissolved oxygen and bubble diameter is 30 ~ 50nm, nanobubbles water dissolved ozone, is a state in which the large surface area of ​​the bubble surface is negatively charged, and of nanobubbles.  The concentration of dissolved oxygen and ozone in the range of 80 ~ 120ppm is preferred.  The reason is because it does not use them because if it is outside the above range, with the aim to stabilize highly dispersed components, it is a chemical component to the preservatives or stabilizers of component to be used is generally It is one that circulation in the body and it was determined the activity by absorption. 
Then, I will explain a method for manufacturing of blood flow improving agent of the present invention.  As shown in Figure 4, the step of purifying pure water (1) reverse osmosis membrane device, the step of filling the container (2) the purified water, blood flow improving agent of the present invention, (3) marine It can be produced by after the step of 1.000 ml for purified water and 2-5 ml liquid volume filling, capping the container, an organic compound. 
In addition, I will describe another method of manufacturing of blood flow improving agent of the present invention.  As shown in Figure 5, the step of purifying pure water (1) reverse osmosis membrane device, the step of filling the container (2) the purified water, blood flow improving agent of the present invention, (3) marine for 1.000 ml of purified water, and 5-9 ml, step 1.000 ml for purified water and 2-5 ml liquid volume filling, amino acids and minerals vegetable fulvic acid derived from an organic compound It can be prepared by through the filling and capping the container. 
In addition, I will describe another method of manufacturing of blood flow improving agent of the present invention.  As shown in Figure 6, the step of purifying pure water (1) reverse osmosis membrane device, the step of filling the container (2) the purified water, blood flow improving agent of the present invention, (3) marine step for 1.000 ml purified water and 3-7 ml liquid volume filling, fulvic acid, a step of 1.000 ml for purified water and 2-5 ml liquid volume filling, trace elements, organic compounds It can be produced by after the step of 1.000 ml for purified water and 5-9 ml filling, amino acids and minerals vegetable derived, capping the container. 
Furthermore, step (1) is a step of processing the nanobubbles water purified pure water reverse osmosis membrane apparatus, and dissolved oxygen or ozone, step (2) to dissolved oxygen or ozone above the After washing the filling container with nanobubble water may, as described above, in the step (2), and wash the filling container with nanobubbles water comprising the steps of filling the container nanobubbles water dissolved oxygen or ozone that it has added a step of are those that use a sterilizing force nanobubble water has, also serving as a cleaning of the vessel.  The generation of nanobubbles water, it is possible to use the micro-nano bubble generator described above. 
Next, based on examples, and the present invention is described in more detail, but the present invention is not intended to be limited thereby. 
Example 1 
After purification of the pure water (1) reverse osmosis membrane apparatus, was used (BUVITAS (shares) Kyowa machine 設製) micro-nano bubble generator pure water purified, and adjusted nanobubbles water was dissolved oxygen.  At this time, the ratio of dissolved ozone and dissolved oxygen was about 80 ~ 90ppm.  After washing the filling container with nanobubble water were dissolved oxygen or ozone which is (2) product, and packed in a container, for 1.000 ml nanobubble water, 2 ml solution, and (3) marine organic compound After filling amount, and capping the container. 
Example 2 
Except that omit the step of using the purified water in place of the nano-bubble water to wash the vessel of step (2) was prepared in the same manner as in Example 1. 
Example 3 
After purification of the pure water (1) reverse osmosis membrane apparatus, was used (BUVITAS (shares) Kyowa machine 設製) micro-nano bubble generator pure water purified, and adjusted nanobubbles water was dissolved oxygen.  At this time, the ratio of dissolved ozone and dissolved oxygen was about 80 ~ 90ppm.  After washing the filling container with nanobubble water were dissolved oxygen or ozone which is (2) product, and packed in a container, for 1.000 ml nanobubble water, 2 ml solution, and (3) marine organic compound The amount of filling, after the relative nanobubble 1.000 ml water, and 5 ml packed, and capping containers, amino acids and minerals vegetable fulvic acid-derived. 
Example 4 
Except that omit the step of using the purified water in place of the nano-bubble water to wash the vessel of step (2) was prepared in the same manner as in Example 3. 
Example 5 
After purification of the pure water (1) reverse osmosis membrane apparatus, was used (BUVITAS (shares) Kyowa machine 設製) micro-nano bubble generator pure water purified, and adjusted nanobubbles water was dissolved oxygen.  At this time, the ratio of dissolved ozone and dissolved oxygen was about 80 ~ 90ppm.  After washing the filling container with nanobubble water were dissolved oxygen or ozone which is (2) product, and packed in a container, for 1.000 ml nanobubble water, 2 ml solution, and (3) marine organic compound The amount of filling, to 1.000 ml nano bubble water, 3 ml fluid volume filling, trace elements, to 1.000 ml nano bubble water, and 5 ml filling, minerals and amino acids of vegetable origin of fulvic acid After, it was capping the container. 
Example 6 
Except that omit the step of using the purified water in place of the nano-bubble water to wash the vessel of step (2) was prepared in the same manner as in Example 5. 
Comparative Example 1 
For Example 5, of the step (3), except that was capped container without the addition of amino acids and minerals vegetable fulvic acid-derived marine organic compounds, and trace elements, prepared in the same manner as in Example 5 was. 
(Measurement of blood flow increase value) 
Was assessed by laser Doppler device, blood flow in the capillary activity of Comparative Example 1 and Examples 1 and 2. 
Is measured using the Moor Instruments Ltd manufactured DRT-4-type, laser Doppler device used, after healthy subjects with respect to (35 year old man) was measured peripheral blood flow in the left middle finger before ingestion conditions, is allowed to ingest the drug blood flow improving agent prepared in Example 1 and was prepared in Comparative Example 1, a 10-fold dilution water, again, the average measured three times (each sequentially measured peripheral blood flow at a given time observation by value), I was evaluated. 
Next, it is observed that the time course of effects persist while descending from the most elevated levels of blood flow, was evaluated.  I and the results are shown in Table 1.  Reference numeral 1 is a graph showing the temporal change of blood flow rising value of the blood flow improving agent of Example 1, reference numeral 2 shows the time course of blood flow rising value of the blood flow improving agent of Example 2 a graph, reference numeral 7 is a graph showing the temporal change of blood flow rising value of the blood flow improving agent of Comparative Example 1. 

Figure JPOXMLDOC01-appb-T000001

I have measured blood flow increased value in the same way in Example 1 and Comparative Example 3 and 4.  I and the results are shown in Table 2.  Reference numeral 3 is a graph showing the temporal change of blood flow rising value of the blood flow improving agent of Example 3, reference numeral 4 shows the time course of blood flow rising value of the blood flow improving agent of Example 4 is a graph. 

Figure JPOXMLDOC01-appb-T000002

I have measured blood flow increased value in the same way in Example 1 and Comparative Example 5 and 6.  I Table 3 shows the results.  Reference numeral 5 is a graph showing the temporal change of blood flow rising value of the blood flow improving agent of Example 5, reference numeral 6 shows a time course of blood flow rising value of the blood flow improving agent of Example 6 is a graph. 

Figure JPOXMLDOC01-appb-T000003

As shown in Figures 1-3, that as compared to the case of using the blood flow improving agent of Examples 1 to 6, and when using the Comparative Example 1 shows a significant blood flow increase value was found. 
Blood flow improvement of Example 4 4 ​​blood flow elevated levels of blood flow improving agent of Example 3 3 blood flow elevated levels of blood flow improving agent of Example 2 2 blood flow elevated levels of blood flow improving agent of Example 1 1 blood flow increased value of blood flow improving agent of Comparative Example 1 7 blood flow elevated levels of blood flow improving agent of Example 6 6 blood flow elevated levels of blood flow improving agent of Example 5 5 blood flow increases the value of the agent

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